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NEW YORK (AP) — Aspirin, one of the world's oldest and cheapest drugs, has shown remarkable promise in treating colon cancer in people with mutations in a gene that's thought to play a role in the disease.Among patients with the mutations, those who regularly took aspirin lived longer than those who didn't, a major study found. Five years after their cancers were diagnosed, 97 percent of the aspirin users were still alive versus 74 percent of those not taking the drug.Aspirin seemed to make no difference in patients who did not have the mutations.This sort of study can't prove that aspirin caused the better survival, and doctors say more research must confirm the findings before aspirin can be recommended more widely. The study wasn't designed to test aspirin; people were taking it on their own for various reasons.Still, the results suggest that this simple medicine might be the cheapest gene-targeting therapy ever found for cancer. About one-sixth of all colon cancer patients have the mutated gene and might be helped by aspirin. And aspirin costs just pennies a day."It's exciting to think that something that's already in the medicine cabinet may really have an important effect" beyond relieving pain and helping to prevent heart attacks, said Dr. Andrew Chan of Massachusetts General Hospital. He and others from Harvard Medical School led the study, which appears in Thursday's New England Journal of Medicine.Cancers of the colon or rectum are a leading cause of cancer deaths worldwide. More than 140,000 new cases and 51,000 deaths from them are expected this year in the United States,Manolo Blahnik sandals.Several studies suggest that aspirin may help fight cancer, especially colorectal tumors. It is often recommended for people who have colon cancer and others at high risk of developing it. But it's not advised for wider use,Manolo Blahnik shoes, or for cancer prevention,Supra Womens Vaider Shoes, because it can cause serious bleeding in the stomach and gut.What has been lacking,Birkenstock Sandals Men, doctors say, is a good way to tell which people might benefit the most, so aspirin's risks would be justified. Chan's study suggests a way to do that.It involved 964 people diagnosed with various stages of colon cancer who were among nearly 175,000 participants in two health studies based at Harvard that began in the 1980s. Every two years, they filled out surveys on their health habits, including aspirin use.Most had surgery for their cancer, and many also had chemotherapy. They gave tumor tissue samples that could be tested for gene activity. Researchers focused on one gene, PIK3CA, that is involved in a key pathway that fuels cancer's growth and spread. Aspirin seems to blunt that pathway, so the scientists looked at its use in relation to the gene.In those whose tumors had a mutation in that gene, regular aspirin use cut the risk of dying of colon cancer by 82 percent and of dying of any cause by 46 percent during the study period of about 13 years.Only two of the 62 regular aspirin users whose tumors had the mutated gene died within five years of their cancer diagnosis versus 23 of 90 non-aspirin users with such a mutation.The results are "quite exciting," said Dr,Nike Air Max Supra society tk Tar Heels, Musketeers adva. Boris Pasche, a cancer specialist at the University of Alabama at Birmingham who wrote an editorial that appears with the study in the medical journal. Half a dozen drugs are used to treat colon cancer,UGG Classic Mini Boots 5854 cheap Supra tk Subdued Dimon,www.supplyairshoes.com, but only one meaningfully extends survival in people whose cancers have not widely spread, he said."Now we may have aspirin. That's why it's a big deal," Pasche said,www.supplyairshoes.com www.manoloblahnikshoesusa.com Ten.In the study, the dose of aspirin — baby or regular — didn't seem to matter,UGG Classic Mini Boots 5854, just whether any aspirin was regularly used.The test for the gene is not expensive and is simple enough that most cancer centers should be able to do it, Chan and Pasche said.The National Institutes of Health and several foundations paid for the study. One of the 17 authors consults for Bayer, a leading aspirin maker. Pasche has been a paid speaker for two companies that make cancer treatments and has two patent applications under review related to cancer treatment.Researchers warn that aspirin may not be responsible for the improved survival seen in this study. Differences in how the patients' cancer was treated could have played a role.For that reason, they say the next step should be a study where some people with the mutated gene are given aspirin and others are not, so their cancer outcomes can be compared more directly.___Online:Medical journal: www.nejm.org___Marilynn Marchione can be followed at twitterMMarchioneAP Note n°1594
par Spingarn le 28/03/2013 @ 00:16 http://www.suprasneakersamerica.com
AMERICAN LEAGUERays 12, Blue Jays 0TORONTO (AP) — David Price struck out a franchise-record 14 in seven dominant innings, Desmond Jennings hit a pair of solo home runs and the Tampa Bay Rays beat the Toronto Blue Jays 12-0 on Sunday.Price (12-11) broke the team mark for strikeouts shared by Scott Kazmir and James Shields.Price allowed only three singles and walked two. Rays pitchers set a team mark by fanning 18 batters overall. Relievers Brandon Gomes and Cesar Ramos each struck out two.Jennings homered on the first pitch of the game from Brandon Morrow (9-9) and got a career-high four hits,Birkenstock Sandals Men UGG Adirondack Teen booked in Al. He drove in three runs, scored three, drew a walk and also stole a base from the leadoff spot,Nike Air Max 91 UGG Australian outlet Support for Hammon.Sean Rodriguez added a two-run homer and Matt Joyce doubled twice during a six-run ninth as the Rays improved to an AL-best 20-9 since July 28.Price improved to 9-1 with a 1.99 ERA in 11 career starts against Toronto. The Blue Jays lost their fourth straight overall.Twins 11, Tigers 4MINNEAPOLIS (AP) — Luke Hughes hit two home runs to help the Minnesota Twins take out their hitting frustration on Brad Penny and the Detroit Tigers, stopping a seven-game losing streak.Hughes has gone deep three times in two games,Ugg Tassel Short 5835. He drove in five runs for the first time in his career,Nike Air Max 2012, backing Brian Duensing (9-13) and sparking the Twins to just their fourth win against the Tigers in their last 19 meetings.Penny (9-10) gave up eight hits, seven runs and two walks in five innings. He struck out five, but this was another non-Justin Verlander flop by the rotation. The Tigers fell to 52-52 when their dazzling, dominant right-hander doesn't start the game; they're 21-8 when he does.Orioles 2, Yankees 0, 1st gameBALTIMORE (AP) — Rookie Zach Britton allowed four hits over seven innings, and the Baltimore Orioles extended their winning streak to a season-high six games by defeating the New York Yankees in the opener of a split doubleheader.The Orioles had not won six in a row since April 2008.The game was scoreless until the seventh, when Nick Markakis doubled and Vladimir Guerrero singled.It was Deter Jeter's 2,402nd game with New York, breaking a tie with Mickey Mantle for most in a Yankees uniform. Jeter went 0 for 4 as the designated hitter.Yankees second baseman Robinson Cano went 0 for 3, ending his 17-game hitting streak.Britton (8-9) allowed four singles, struck out five and walked one before being pulled after throwing a career-high 120 pitches. Jim Johnson pitched a perfect eighth inning and Kevin Gregg worked the ninth for his 19th save.Bartolo Colon (8-9) has lost his last three starts.Yankees 8, Orioles 3, 2nd gameBALTIMORE (AP) — Curtis Granderson homered twice to take over the major league lead with 38, rookie Ivan Nova won his 10th straight decision, and the New York Yankees beat the Baltimore Orioles 8-3 Sunday night for a split of a day-night doubleheader,www.topsandalssale.com.Granderson hit a three-run drive in the third inning and a solo shot in the seventh. He moved past Jose Bautista, who has 37 homers, and assumed the major league lead in RBIs with 107.Rangers 9, Angels 5ARLINGTON, Texas (AP) — Josh Hamilton broke out of a slump with a long two-run homer and the tiebreaking RBI single for the AL West-leading Texas Rangers, who rallied for a 9-5 victory over the chasing Los Angeles Angels.Hamilton's homer in the third off Jered Weaver tied the game at 4, and his single in the seventh put the Rangers ahead 6-5. The reigning AL MVP had been 3 for 21 on the homestand without an RBI the past four games.Texas (76-59) had lost seven of 10 games, watching its division lead against the Angels shrink from seven games to two, before winning the finale against the Angels. The AL West's top two teams don't play again until a three-game series on the West Coast to end the regular season.Darren Oliver (5-5) pitched a scoreless inning in relief of starter Colby Lewis before the Rangers knocked Weaver (15-7) out of the game.White Sox 9, Mariners 3SEATTLE (AP) — Dayan Viciedo made a sudden impact in his return to the majors,Birkenstock Sandals Men, hitting a three-run homer in his season debut as the Chicago White Sox beat the Seattle Mariners for a sweep.Tyler Flowers connected for his first career grand slam, helping Gavin Floyd (12-10) cruise to victory.Viciedo was called up from Triple-A Charlotte on Saturday when the White Sox placed outfielder Carlos Quentin on the 15-day disabled list.Viciedo put up strong numbers in Charlotte, batting .297 with 20 home runs and 78 RBIs this year. He was up with the White Sox for 38 games in 2010 and hit five home runs with 13 RBIs while batting .308.The newly promoted right fielder singled in his first at-bat, then homered over the right-center field fence off Jason Vargas (7-12) the next time up.Royals 2, Indians 1CLE
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